A Rosowsky Selected Research

N(alpha)- (4- amino- 4- deoxypteroyl)- N(delta)- hemiphthaloyl- L- ornithine (PT 523)

7/2000	Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine (PT523) and its B-ring analogues.
4/2000	Analogues of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: synthesis and in vitro antitumor activity.
3/2000	The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine.

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A Rosowsky Research Topics

Disease

3	Neoplasms (Cancer) 07/2000 - 03/2000
1	Neuroblastoma 08/2001
1	Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency 04/2000
1	Cryptosporidiosis 04/2000

Drug/Important Bio-Agent (IBA)

3	N(alpha)- (4- amino- 4- deoxypteroyl)- N(delta)- hemiphthaloyl- L- ornithine (PT 523)IBA 07/2000 - 03/2000
1	formic acid (formate)IBA 08/2001
1	Folic Acid (Vitamin M)FDA LinkGeneric 08/2001
1	Phospholipids (Phosphatides)FDA LinkGeneric 08/2001
1	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 07/2000
1	Folic Acid AntagonistsIBA 04/2000
1	Pharmaceutical PreparationsIBA 04/2000
1	EnzymesIBA 04/2000